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This study was carried out to investigate the effects of Salicornia herbacea L. (SH) on carbon tetrachloride (CCl₄)-inducedhepatotoxicity. Sprague-Dawley rats were intraperitoneally administered the SH at 100 ㎎/㎏ per day for two weeks. Then single dose of CCl4 (3.3 ml/㎏) was injected into rats. Twelve hours later, they were anesthesized with ether and dissected. SH-CCl₄-administered group showed 65.56% and 59.04% of inhibitory effects in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, compared to CCl₄-treated group (p<0.05). Malonedialdehyde (MDA) levels of SH-CCl₄-administered group in liver homogenate and mitochondria were significantly inhibited by 53.74%, 89.86%, and respectively, compared to CCl₄-treated group (p<0.05). Superoxide dismutase (SOD) activities of SH-CCl₄-administered group in liver homogenate and mitochondria were significantly inhibited by 42.51%, and 38.42%, respectively, compared to CCl₄-treated group (p<0.05). The histological examinations showed that the liver cell necrosis and centrilobular congestive aggregation induced by CCl₄were clearly eliminated by the administration of SH. These results suggest that SH could have the protective effects against hepatotoxicity.
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